The Molecule We’ve Been Missing: Dr. Nathan Bryan on Why Nitric Oxide Could Change Medicine

In the latest episode of Khan Klinics, hosted by Dr. Amir Khan in collaboration with American Muslim Today (AMT), nitric oxide researcher Dr. Nathan S. Bryan laid out a compelling case for why this “miracle molecule” deserves urgent attention.

Despite decades of medical breakthroughs, one life-altering molecule remains largely under the radar—and it may hold the key to combating chronic disease, aging, and even neurodegeneration.

Dr. Bryan, a biochemist and CEO of Nitric Oxide Innovations, has spent over 25 years studying nitric oxide (NO). What he’s discovered, he says, has the potential to reshape how we prevent, manage, and even reverse chronic disease.

“There are only two kinds of people who need nitric oxide—those who are sick and want to get well, and those who are well and want to stay that way,” he stated.

Dr. Nathan S. Bryan

 A Molecule at the Heart of Human Health

Misunderstood and Underutilized

Dr. Khan pressed on why nitric oxide isn’t more widely recognized. Dr. Bryan pointed out a common misconception because nitric oxide is often found at inflammation sites, some assume it contributes to disease.

“That’s like blaming fire trucks for the fire,” he explained. “Nitric oxide is part of the healing process, not the cause of damage.”

While nitric oxide is used clinically in narrow settings, like neonatal care for pulmonary hypertension, its broader applications remain largely untapped.

Diet, Lifestyle, and Disruption

The conversation shifted toward practical implications. Dr. Khan asked ‘How can the average person improve their nitric oxide levels?’

Dr. Bryan’s advice was grounded in data. Eliminate processed sugar. Consume nitrate-rich greens. Avoid fluoride toothpaste and antiseptic mouthwashes. And perhaps most surprisingly—limit the use of antacids, which impair the stomach’s ability to process dietary nitrates.

“If you’re killing your oral microbiome and blocking stomach acid, your body can’t make nitric oxide—no matter how healthy your diet is,” he warned.

Exercise, nasal breathing, sleep, and stress management also emerged as powerful tools for nitric oxide production.

Aging Doesn’t Have to Mean Decline

Nitric oxide levels drop with age, but this decline isn’t inevitable. Dr. Bryan noted that vascular age can be maintained—or even reversed—through consistent lifestyle measures. Genetics may play a role, but daily choices matter more.

“I’m 51, but my vascular age is 36,” he shared.

In a breakthrough 2007 study, Dr. Bryan’s team proved that nitric oxide functions like a hormone, produced in one part of the body but having effects elsewhere. This redefined how scientists think about nitric oxide and opened the door to therapeutic applications.

Real-World Impact: COVID, Heart Disease, and Alzheimer’s

During the COVID-19 pandemic, Dr. Bryan led a clinical study using a nitric oxide lozenge to treat high-risk patients. The results were encouraging: faster recovery, improved oxygen levels, and no adverse reactions, highlighting the molecule’s immune-supportive role.

He’s now preparing FDA trials targeting heart disease, chronic wounds, and Alzheimer’s. On the latter, Dr. Bryan is optimistic.

“Alzheimer’s is fundamentally a vascular and metabolic disease. Nitric oxide improves blood flow, reduces inflammation, and restores insulin signaling. I believe we can reverse it,” he said.

To wrap up, Dr. Bryan urged listeners to take charge of their health by learning about nitric oxide. His latest book, The Secret of Nitric Oxide: Bringing the Science to Life, breaks down the science and offers actionable tips.

“We’re not just treating symptoms anymore—we’re targeting root causes,” he said. “This molecule is the future of medicine.”

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